Effects of dietary transgenic poplar leaf pellets on performance and tissues in rabbits.
Identifieur interne : 002263 ( Main/Exploration ); précédent : 002262; suivant : 002264Effects of dietary transgenic poplar leaf pellets on performance and tissues in rabbits.
Auteurs : Liyan Yang [République populaire de Chine] ; Yi Sun ; Yixue Wang ; Yaoshan HaoSource :
- Journal of the science of food and agriculture [ 1097-0010 ] ; 2014.
Descripteurs français
- KwdFr :
- Aliment génétiquement modifié (effets indésirables), Aliment pour animaux (MeSH), Animaux (MeSH), Chitinase (génétique), Consommation alimentaire (MeSH), Distribution tissulaire (MeSH), Femelle (MeSH), Feuilles de plante (MeSH), Insectes (génétique), Lapins (MeSH), Mâle (MeSH), Métabolisme énergétique (MeSH), Populus (génétique), Prise de poids (MeSH), Régime alimentaire (MeSH), Venins de scorpion (génétique), Végétaux génétiquement modifiés (MeSH).
- MESH :
- effets indésirables : Aliment génétiquement modifié.
- génétique : Chitinase, Insectes, Populus, Venins de scorpion.
- Aliment pour animaux, Animaux, Consommation alimentaire, Distribution tissulaire, Femelle, Feuilles de plante, Lapins, Mâle, Métabolisme énergétique, Prise de poids, Régime alimentaire, Végétaux génétiquement modifiés.
English descriptors
- KwdEn :
- Animal Feed (MeSH), Animals (MeSH), Chitinases (genetics), Diet (MeSH), Eating (MeSH), Energy Metabolism (MeSH), Female (MeSH), Food, Genetically Modified (adverse effects), Insecta (genetics), Male (MeSH), Plant Leaves (MeSH), Plants, Genetically Modified (MeSH), Populus (genetics), Rabbits (MeSH), Scorpion Venoms (genetics), Tissue Distribution (MeSH), Weight Gain (MeSH).
- MESH :
- chemical , genetics : Chitinases, Scorpion Venoms.
- adverse effects : Food, Genetically Modified.
- genetics : Insecta, Populus.
- Animal Feed, Animals, Diet, Eating, Energy Metabolism, Female, Male, Plant Leaves, Plants, Genetically Modified, Rabbits, Tissue Distribution, Weight Gain.
Abstract
BACKGROUND
Various studies have been conducted to evaluate the effect of Bt crops on animals. Insect-resistant bioassays have revealed that the chitinase-BmkIT combination could be used as a new pest-resistant gene source and might be a complementary alien gene source to the Bt toxin gene. So it is necessary to assay the effects of chitinase-BmkIT plants on animals.
RESULTS
Forty 40-day old New Zealand White Rabbits (Oryctolagus cuniculus) were fed for 60 consecutive days with formulated feed containing dehydrated poplar (Populus cathayana Rehd) leaves harbouring chitinase-BmkIT gene combination or untransformed counterparts, and the potential toxicological effects of transgenic leaves on rabbits were explored. The results of the growth study revealed no significant differences for daily weight gain, feed intake and feed conversion ratio where they were 101.6%, 99.2% and 97.8% of the treatment compared to the control, respectively. No obvious pathological change was observed in the small intestine, stomach, spleen, kidney, lung, heart, bladder, pancreas, prostate and ovary. Electron microscopy observations of liver cells and renal cells showed they were both normal in the two groups. No feed-derived chitinase, BmkIT and NPTII genes were found in small intestine, blood, or leg muscle samples although they were detected in the formulated feed.
CONCLUSION
We conclude that the processed poplar leaves with foreign chitinase-BmkIT genes had no obviously harmful effects on rabbits.
DOI: 10.1002/jsfa.6388
PubMed: 24027136
Affiliations:
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department Life Science, Shanxi Normal University, Linfen, 041004</wicri:regionArea><wicri:noRegion>041004</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name></author><author><name sortKey="Wang, Yixue" sort="Wang, Yixue" uniqKey="Wang Y" first="Yixue" last="Wang">Yixue Wang</name></author><author><name sortKey="Hao, Yaoshan" sort="Hao, Yaoshan" uniqKey="Hao Y" first="Yaoshan" last="Hao">Yaoshan Hao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24027136</idno><idno type="pmid">24027136</idno><idno type="doi">10.1002/jsfa.6388</idno><idno type="wicri:Area/Main/Corpus">002470</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002470</idno><idno type="wicri:Area/Main/Curation">002470</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002470</idno><idno type="wicri:Area/Main/Exploration">002470</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of dietary transgenic poplar leaf pellets on performance and tissues in rabbits.</title><author><name sortKey="Yang, Liyan" sort="Yang, Liyan" uniqKey="Yang L" first="Liyan" last="Yang">Liyan Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department Life Science, Shanxi Normal University, Linfen, 041004, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department Life Science, Shanxi Normal University, Linfen, 041004</wicri:regionArea><wicri:noRegion>041004</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name></author><author><name sortKey="Wang, Yixue" sort="Wang, Yixue" uniqKey="Wang Y" first="Yixue" last="Wang">Yixue Wang</name></author><author><name sortKey="Hao, Yaoshan" sort="Hao, Yaoshan" uniqKey="Hao Y" first="Yaoshan" last="Hao">Yaoshan Hao</name></author></analytic><series><title level="j">Journal of the science of food and agriculture</title><idno type="eISSN">1097-0010</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal Feed (MeSH)</term><term>Animals (MeSH)</term><term>Chitinases (genetics)</term><term>Diet (MeSH)</term><term>Eating (MeSH)</term><term>Energy Metabolism (MeSH)</term><term>Female (MeSH)</term><term>Food, Genetically Modified (adverse effects)</term><term>Insecta (genetics)</term><term>Male (MeSH)</term><term>Plant Leaves (MeSH)</term><term>Plants, Genetically Modified (MeSH)</term><term>Populus (genetics)</term><term>Rabbits (MeSH)</term><term>Scorpion Venoms (genetics)</term><term>Tissue Distribution (MeSH)</term><term>Weight Gain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aliment génétiquement modifié (effets indésirables)</term><term>Aliment pour animaux (MeSH)</term><term>Animaux (MeSH)</term><term>Chitinase (génétique)</term><term>Consommation alimentaire (MeSH)</term><term>Distribution tissulaire (MeSH)</term><term>Femelle (MeSH)</term><term>Feuilles de plante (MeSH)</term><term>Insectes (génétique)</term><term>Lapins (MeSH)</term><term>Mâle (MeSH)</term><term>Métabolisme énergétique (MeSH)</term><term>Populus (génétique)</term><term>Prise de poids (MeSH)</term><term>Régime alimentaire (MeSH)</term><term>Venins de scorpion (génétique)</term><term>Végétaux génétiquement modifiés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chitinases</term><term>Scorpion Venoms</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Food, Genetically Modified</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Aliment génétiquement modifié</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Insecta</term><term>Populus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chitinase</term><term>Insectes</term><term>Populus</term><term>Venins de scorpion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animal Feed</term><term>Animals</term><term>Diet</term><term>Eating</term><term>Energy Metabolism</term><term>Female</term><term>Male</term><term>Plant Leaves</term><term>Plants, Genetically Modified</term><term>Rabbits</term><term>Tissue Distribution</term><term>Weight Gain</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aliment pour animaux</term><term>Animaux</term><term>Consommation alimentaire</term><term>Distribution tissulaire</term><term>Femelle</term><term>Feuilles de plante</term><term>Lapins</term><term>Mâle</term><term>Métabolisme énergétique</term><term>Prise de poids</term><term>Régime alimentaire</term><term>Végétaux génétiquement modifiés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Various studies have been conducted to evaluate the effect of Bt crops on animals. Insect-resistant bioassays have revealed that the chitinase-BmkIT combination could be used as a new pest-resistant gene source and might be a complementary alien gene source to the Bt toxin gene. So it is necessary to assay the effects of chitinase-BmkIT plants on animals.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Forty 40-day old New Zealand White Rabbits (Oryctolagus cuniculus) were fed for 60 consecutive days with formulated feed containing dehydrated poplar (Populus cathayana Rehd) leaves harbouring chitinase-BmkIT gene combination or untransformed counterparts, and the potential toxicological effects of transgenic leaves on rabbits were explored. The results of the growth study revealed no significant differences for daily weight gain, feed intake and feed conversion ratio where they were 101.6%, 99.2% and 97.8% of the treatment compared to the control, respectively. No obvious pathological change was observed in the small intestine, stomach, spleen, kidney, lung, heart, bladder, pancreas, prostate and ovary. Electron microscopy observations of liver cells and renal cells showed they were both normal in the two groups. No feed-derived chitinase, BmkIT and NPTII genes were found in small intestine, blood, or leg muscle samples although they were detected in the formulated feed.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>We conclude that the processed poplar leaves with foreign chitinase-BmkIT genes had no obviously harmful effects on rabbits.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24027136</PMID><DateCompleted><Year>2014</Year><Month>11</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0010</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of the science of food and agriculture</Title><ISOAbbreviation>J Sci Food Agric</ISOAbbreviation></Journal><ArticleTitle>Effects of dietary transgenic poplar leaf pellets on performance and tissues in rabbits.</ArticleTitle><Pagination><MedlinePgn>1163-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/jsfa.6388</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Various studies have been conducted to evaluate the effect of Bt crops on animals. Insect-resistant bioassays have revealed that the chitinase-BmkIT combination could be used as a new pest-resistant gene source and might be a complementary alien gene source to the Bt toxin gene. So it is necessary to assay the effects of chitinase-BmkIT plants on animals.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Forty 40-day old New Zealand White Rabbits (Oryctolagus cuniculus) were fed for 60 consecutive days with formulated feed containing dehydrated poplar (Populus cathayana Rehd) leaves harbouring chitinase-BmkIT gene combination or untransformed counterparts, and the potential toxicological effects of transgenic leaves on rabbits were explored. The results of the growth study revealed no significant differences for daily weight gain, feed intake and feed conversion ratio where they were 101.6%, 99.2% and 97.8% of the treatment compared to the control, respectively. No obvious pathological change was observed in the small intestine, stomach, spleen, kidney, lung, heart, bladder, pancreas, prostate and ovary. Electron microscopy observations of liver cells and renal cells showed they were both normal in the two groups. No feed-derived chitinase, BmkIT and NPTII genes were found in small intestine, blood, or leg muscle samples although they were detected in the formulated feed.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We conclude that the processed poplar leaves with foreign chitinase-BmkIT genes had no obviously harmful effects on rabbits.</AbstractText><CopyrightInformation>© 2013 Society of Chemical Industry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Liyan</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department Life Science, Shanxi Normal University, Linfen, 041004, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yixue</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hao</LastName><ForeName>Yaoshan</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Sci Food Agric</MedlineTA><NlmUniqueID>0376334</NlmUniqueID><ISSNLinking>0022-5142</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C485978">BmK alphaIT1 toxin, Buthus martensii</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012604">Scorpion Venoms</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.14</RegistryNumber><NameOfSubstance UI="D002688">Chitinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000821" MajorTopicYN="Y">Animal Feed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002688" MajorTopicYN="N">Chitinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="Y">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004435" MajorTopicYN="N">Eating</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004734" MajorTopicYN="N">Energy 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MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012604" MajorTopicYN="N">Scorpion Venoms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015430" MajorTopicYN="N">Weight Gain</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">biosafety</Keyword><Keyword MajorTopicYN="N">feed</Keyword><Keyword MajorTopicYN="N">rabbit</Keyword><Keyword MajorTopicYN="N">transgenic poplar</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>05</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>09</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>09</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24027136</ArticleId><ArticleId IdType="doi">10.1002/jsfa.6388</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Hao, Yaoshan" sort="Hao, Yaoshan" uniqKey="Hao Y" first="Yaoshan" last="Hao">Yaoshan Hao</name><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name><name sortKey="Wang, Yixue" sort="Wang, Yixue" uniqKey="Wang Y" first="Yixue" last="Wang">Yixue Wang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Liyan" sort="Yang, Liyan" uniqKey="Yang L" first="Liyan" last="Yang">Liyan Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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